Abstract Background In high throughput cancer genomic studies, results from the analysis of single datasets often suffer from a lack of reproducibility because of small sample sizes.Integrative analysis can effectively pool and analyze multiple datasets and provides a cost effective way to improve reproducibility.In integrative analysis, simultaneo
Deciphering the Mechanism of Gilteritinib Overcoming Lorlatinib Resistance to the Double Mutant I1171N/F1174I in Anaplastic Lymphoma Kinase
Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple malignancies, such as non-small cell lung cancer (NSCLC).However, the feasibility of targeted therapies Hearing Aids exerted by ALK inhibitors is inevitably hindered owing to drug resistance.The emergence of clinically acquired drug mutations has become a ma
Impact Assessments of Transgenic cry1Ab Rice on the Population Dynamics of Five Non-Target Thrips Species and Their General Predatory Flower Bug in Bt and Non-Bt Rice Fields Using Color Sticky Card Traps
A 2-yr field study was conducted to assess the effects of transgenic japonica rice (KMD1 and KMD2) with a synthetic cry1Ab gene from Bacillus thuingiensis Berliner on population dynamics and seasonal average densities of five thrips species including Stenchaetothrips biformis (Bagnall), Frankliniella intonsa (Trybom), F.tenuicornis (Uzel), Haplothr